Craig Horbinsky, neuropathologist at the University of Kentucky, and his team developed an interactive online-tool for the selection of brain tumor cases which might benefit from additional molecular testing. The Horbinsky team established an algorithm which calculates a statistical probability score by assembling parameters which can be obtained easily by a pathologist, e.g. WHO grade and patient age. Moreover, the tool differentiates IDH1 R132H immunostain negative cases from cases without previous testing and provides separate scores. This tool might help to better triage brain tumor cases for additional molecular testing.

Online-tool for predicting likelihood of IDH1/2 mutation in glioma

For more information please follow Brain E. Moore’s Neuropatholgy Blog